Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC041
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-30 10:55
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 11 individuals with a value less than 0.55 were subsequently diagnosed with PD. That is, 26.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.55 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 19, 'TN': 9, 'TP': 23, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.584
timePerCircleCoV 0.165331
timePerCircleSlope -0.0387996
meanError 1.35775
tremorFreq 6.83594
tremorRelPower 24.6258
tremorGyroAmpMean 0.0161094
tremorGyroAmpSlope 0.00150191
tremorGyroAmpCoV 0.310748
tremorCoordAmpMean 0.0280078
tremorCoordAmpSlope 0.00379856
tremorCoordAmpCoV 0.304361
tremorAccAmpMean 0.0161051
tremorAccAmpSlope 0.00203171
tremorAccAmpCoV 0.293894
tremorPcRelVar 0.580845
tremorPcX -0.99416
tremorPcY 0.10792

Circle Segment 1

Duration 16.08 s, Accuracy Estimate 1.305 (lower is better)

Circle Segment 2

Duration 12.84 s, Accuracy Estimate 1.128 (lower is better)

Circle Segment 3

Duration 11.24 s, Accuracy Estimate 1.143 (lower is better)

Circle Segment 4

Duration 10.36 s, Accuracy Estimate 0.966 (lower is better)

Circle Segment 5

Duration 11.52 s, Accuracy Estimate 1.43 (lower is better)

Circle Segment 6

Duration 10.56 s, Accuracy Estimate 1.216 (lower is better)

Circle Segment 7

Duration 12.44 s, Accuracy Estimate 1.375 (lower is better)

Circle Segment 8

Duration 11.08 s, Accuracy Estimate 1.041 (lower is better)

Circle Segment 9

Duration 10.76 s, Accuracy Estimate 1.189 (lower is better)

Circle Segment 10

Duration 8.96 s, Accuracy Estimate 2.785 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 34.87
timePerSpiralCoV 0.0622463
timePerSpiralSlope -0.00718314
meanError 1.53407
tremorFreq 6.73828
tremorRelPower 27.1815
tremorGyroAmpMean 0.0228649
tremorGyroAmpSlope 0.00195973
tremorGyroAmpCoV 0.35154
tremorCoordAmpMean 0.0916658
tremorCoordAmpSlope 0.00235885
tremorCoordAmpCoV 1.78394
tremorAccAmpMean 0.0216679
tremorAccAmpSlope 0.00175738
tremorAccAmpCoV 0.350243
tremorPcRelVar 0.512503
tremorPcX -0.143489
tremorPcY -0.989652

Spiral Segment 1

Duration 38.32 s, Accuracy Estimate 1.387 (lower is better)

Spiral Segment 2

Duration 35.64 s, Accuracy Estimate 1.426 (lower is better)

Spiral Segment 3

Duration 33.44 s, Accuracy Estimate 1.594 (lower is better)

Spiral Segment 4

Duration 34.44 s, Accuracy Estimate 1.6 (lower is better)

Spiral Segment 5

Duration 30.8 s, Accuracy Estimate 1.736 (lower is better)

Spiral Segment 6

Duration 36.12 s, Accuracy Estimate 1.409 (lower is better)

Spiral Segment 7

Duration 35.2 s, Accuracy Estimate 1.522 (lower is better)

Spiral Segment 8

Duration 35.0 s, Accuracy Estimate 1.598 (lower is better)

Elel

eDurationMean 0.682976
eDurationStd 0.118523
eDurationStdnorm 0.173539
eDurationMedian 0.6625
eDurationQuartdelta 0.1
eDurationQuartdeltanorm 0.150943
eDurationKurt 4.17565
eDurationTrenddiff -0.095
eDurationTrendratio 0.868966
eWidthMean 4.55464
eWidthStd 1.03988
eWidthStdnorm 0.228313
eWidthMedian 4.563
eWidthQuartdelta 1.17
eWidthQuartdeltanorm 0.25641
eWidthKurt 3.8131
eWidthTrenddiff 0.234
eWidthTrendratio 1.05405
eHeightMean 7.05621
eHeightStd 1.01818
eHeightStdnorm 0.144295
eHeightMedian 7.0785
eHeightQuartdelta 1.17
eHeightQuartdeltanorm 0.165289
eHeightKurt 4.02556
eHeightTrenddiff 0.234
eHeightTrendratio 1.0339
eAspectMean 0.645732
eAspectStd 0.114436
eAspectStdnorm 0.177219
eAspectMedian 0.629736
eAspectQuartdelta 0.125262
eAspectQuartdeltanorm 0.198912
eAspectKurt 4.12958
eAspectTrenddiff 0.0052343
eAspectTrendratio 1.00835
eSlantMean -0.10255
eSlantStd 0.213092
eSlantStdnorm -2.07792
eSlantMedian -0.075565
eSlantQuartdelta 0.223111
eSlantQuartdeltanorm -2.95257
eSlantKurt 3.99264
eSlantTrenddiff 0.188814
eRtopMean 0.600087
eRtopStd 0.119833
eRtopStdnorm 0.199693
eRtopMedian 0.615385
eRtopQuartdelta 0.185714
eRtopQuartdeltanorm 0.301786
eRtopKurt 2.32783
eRtopTrenddiff 0.0649351
eRbotMean 0.768033
eRbotStd 0.277829
eRbotStdnorm 0.361742
eRbotMedian 0.753788
eRbotQuartdelta 0.276292
eRbotQuartdeltanorm 0.366539
eRbotKurt 4.39276
eRbotTrenddiff -0.214865
eRrightMean 0.786449
eRrightStd 0.0725375
eRrightStdnorm 0.0922342
eRrightMedian 0.801639
eRrightQuartdelta 0.121826
eRrightQuartdeltanorm 0.151971
eRrightKurt 2.06552
eRrightTrenddiff 0.00327869
eRleftMean 0.443309
eRleftStd 0.110716
eRleftStdnorm 0.249749
eRleftMedian 0.444388
eRleftQuartdelta 0.144725
eRleftQuartdeltanorm 0.325671
eRleftKurt 2.83306
eRleftTrenddiff -0.128852
lDurationMean 0.845238
lDurationStd 0.162664
lDurationStdnorm 0.192448
lDurationMedian 0.825
lDurationQuartdelta 0.185
lDurationQuartdeltanorm 0.224242
lDurationKurt 8.42008
lDurationTrenddiff -0.18
lDurationTrendratio 0.803279
lWidthMean 5.9865
lWidthStd 1.39108
lWidthStdnorm 0.232369
lWidthMedian 5.85
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.28
lWidthKurt 2.57177
lWidthTrenddiff 0.468
lWidthTrendratio 1.08511
lHeightMean 14.0511
lHeightStd 2.26942
lHeightStdnorm 0.161512
lHeightMedian 13.9815
lHeightQuartdelta 2.808
lHeightQuartdeltanorm 0.200837
lHeightKurt 2.85561
lHeightTrenddiff 0.468
lHeightTrendratio 1.03448
lAspectMean 0.434344
lAspectStd 0.112471
lAspectStdnorm 0.258945
lAspectMedian 0.415346
lAspectQuartdelta 0.148148
lAspectQuartdeltanorm 0.356686
lAspectKurt 2.72742
lAspectTrenddiff -0.0171334
lAspectTrendratio 0.959583
lSlantMean -0.0402819
lSlantStd 0.159668
lSlantStdnorm -3.96377
lSlantMedian -0.0494639
lSlantQuartdelta 0.20723
lSlantQuartdeltanorm -4.18951
lSlantKurt 2.55305
lSlantTrenddiff 0.158156
lRtopMean 0.656199
lRtopStd 0.129472
lRtopStdnorm 0.197306
lRtopMedian 0.654681
lRtopQuartdelta 0.191453
lRtopQuartdeltanorm 0.292437
lRtopKurt 2.67273
lRtopTrenddiff 0.0423242
lRbotMean 0.803582
lRbotStd 0.290536
lRbotStdnorm 0.361551
lRbotMedian 0.782857
lRbotQuartdelta 0.423256
lRbotQuartdeltanorm 0.540655
lRbotKurt 2.39751
lRbotTrenddiff -0.268127
lRrightMean 0.805128
lRrightStd 0.103866
lRrightStdnorm 0.129006
lRrightMedian 0.822307
lRrightQuartdelta 0.156
lRrightQuartdeltanorm 0.18971
lRrightKurt 5.05069
lRrightTrenddiff -0.00405306
lRleftMean 0.410063
lRleftStd 0.161827
lRleftStdnorm 0.394638
lRleftMedian 0.398198
lRleftQuartdelta 0.235085
lRleftQuartdeltanorm 0.590372
lRleftKurt 2.19735
lRleftTrenddiff -0.214286

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.851829
sumTouchScores 11.9256
meanMovementTime 1.18962
numTouches 14
undershootPercentage 0
overshootPercentage 14.2857

FITTS Long Modified

meanTouchScore 0.854328
sumTouchScores 12.8149
meanMovementTime 1.15143
numTouches 15
undershootPercentage 6.66667
overshootPercentage 13.3333

ZigZag

numZigzags 5
timePerZigzagMean 27.328
timePerZigzagCoV 0.0551118
timePerZigzagSlope 0.00892857
meanError 2.3285
tremorFreq 6.83594
tremorRelPower 25.6559
tremorGyroAmpMean 0.0243105
tremorGyroAmpSlope -0.000123039
tremorGyroAmpCoV 0.354975
tremorCoordAmpMean 0.0844944
tremorCoordAmpSlope -0.00237481
tremorCoordAmpCoV 0.932036
tremorAccAmpMean 0.0326517
tremorAccAmpSlope 0.000584428
tremorAccAmpCoV 0.416385
tremorPcRelVar 0.843725
tremorPcX -0.126027
tremorPcY -0.992027

ZigZag Segment 1

Duration 26.48 s, Accuracy Estimate 2.074 (lower is better)

ZigZag Segment 2

Duration 26.72 s, Accuracy Estimate 2.445 (lower is better)

ZigZag Segment 3

Duration 27.44 s, Accuracy Estimate 2.315 (lower is better)

ZigZag Segment 4

Duration 29.88 s, Accuracy Estimate 2.136 (lower is better)

ZigZag Segment 5

Duration 26.12 s, Accuracy Estimate 2.672 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 20.68
timePerZigzagCoV 0.0823244
timePerZigzagSlope -0.0415861
zigzagHeightMean 55.9874
zigzagHeightCoV 0.0506204
zigzagHeightSlope 0.0289207
meanError 0.0405891
tremorFreq 6.83594
tremorRelPower 30.6203
tremorGyroAmpMean 0.0265001
tremorGyroAmpSlope -0.00119506
tremorGyroAmpCoV 0.446448
tremorCoordAmpMean 0.10758
tremorCoordAmpSlope -0.00176588
tremorCoordAmpCoV 0.882334
tremorAccAmpMean 0.0333601
tremorAccAmpSlope 0.00263324
tremorAccAmpCoV 0.411797
tremorPcRelVar 0.873497
tremorPcX -0.0841223
tremorPcY 0.996455

ZigZag Offset Segment 1

Duration 22.04 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 22.36 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 3

Duration 19.52 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 4

Duration 21.12 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 18.36 s, Accuracy Estimate 0.044 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.29}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.55}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.3383711910337457}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8393718499202043}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.791248638045801}